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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR2A
All Species:
23.03
Human Site:
S312
Identified Species:
33.78
UniProt:
P13861
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13861
NP_004148.1
404
45518
S312
E
V
S
I
L
I
R
S
R
T
K
S
N
K
D
Chimpanzee
Pan troglodytes
XP_001148361
477
52826
R386
E
V
K
I
T
M
K
R
K
G
K
S
E
V
E
Rhesus Macaque
Macaca mulatta
XP_001089109
461
51060
R370
E
V
K
I
T
M
K
R
K
G
K
S
E
V
E
Dog
Lupus familis
XP_541890
401
45078
S309
E
V
S
I
L
I
R
S
K
T
K
A
N
K
D
Cat
Felis silvestris
Mouse
Mus musculus
P12367
401
45371
S309
E
V
S
I
L
I
R
S
K
T
K
S
N
K
N
Rat
Rattus norvegicus
P12368
401
45522
S309
E
V
S
I
L
I
R
S
K
T
K
T
N
K
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509189
323
36258
G252
E
I
A
R
Y
S
R
G
Q
Y
F
G
E
L
A
Chicken
Gallus gallus
Q5ZM91
382
43332
R307
T
A
A
V
L
Q
R
R
S
E
N
E
E
F
V
Frog
Xenopus laevis
NP_001084637
402
45172
S311
E
V
R
I
T
M
K
S
K
S
K
P
D
A
E
Zebra Danio
Brachydanio rerio
NP_001070838
397
44672
S309
E
V
K
I
M
M
K
S
K
T
K
A
D
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P81900
377
42730
Q293
T
V
S
V
R
M
D
Q
D
D
A
E
V
E
I
Honey Bee
Apis mellifera
XP_392905
383
43849
G299
I
V
R
I
T
I
R
G
D
D
G
R
E
I
E
Nematode Worm
Caenorhab. elegans
P30625
366
41449
R291
E
A
N
V
L
Q
K
R
S
D
D
A
P
F
D
Sea Urchin
Strong. purpuratus
Q26619
369
41770
S290
Q
C
R
I
A
M
K
S
E
R
S
D
N
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
I329
I
Y
Q
P
G
E
T
I
I
R
E
G
D
Q
G
Red Bread Mold
Neurospora crassa
Q01386
385
42138
G312
E
A
A
A
F
K
R
G
N
D
S
P
V
K
N
Conservation
Percent
Protein Identity:
100
58.4
61.1
91
N.A.
86.8
86.8
N.A.
58.6
35.1
64.8
71.2
N.A.
48.7
49.7
32.9
52.2
Protein Similarity:
100
68.3
70.7
94.5
N.A.
91.3
92
N.A.
69
52.7
80.6
83.6
N.A.
67.8
69
54.9
69
P-Site Identity:
100
33.3
33.3
86.6
N.A.
86.6
80
N.A.
13.3
13.3
33.3
40
N.A.
13.3
26.6
20
26.6
P-Site Similarity:
100
60
60
100
N.A.
100
100
N.A.
33.3
26.6
73.3
86.6
N.A.
33.3
33.3
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
37.2
35.4
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
55.2
51.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
19
7
7
0
0
0
0
0
7
19
0
7
7
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
7
0
13
25
7
7
19
0
25
% D
% Glu:
69
0
0
0
0
7
0
0
7
7
7
13
32
7
25
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
7
0
0
13
0
% F
% Gly:
0
0
0
0
7
0
0
19
0
13
7
13
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
13
7
0
63
0
32
0
7
7
0
0
0
0
7
7
% I
% Lys:
0
0
19
0
0
7
38
0
44
0
50
0
0
32
0
% K
% Leu:
0
0
0
0
38
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
0
0
7
38
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
7
0
7
0
32
0
19
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
0
13
7
7
0
% P
% Gln:
7
0
7
0
0
13
0
7
7
0
0
0
0
7
7
% Q
% Arg:
0
0
19
7
7
0
50
25
7
13
0
7
0
7
0
% R
% Ser:
0
0
32
0
0
7
0
44
13
7
13
25
0
0
0
% S
% Thr:
13
0
0
0
25
0
7
0
0
32
0
7
0
0
0
% T
% Val:
0
63
0
19
0
0
0
0
0
0
0
0
13
13
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
7
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _